Abstract
Sulfones are versatile intermediates in organic synthesis and important building blocks in the construction of biological active molecules or functional materials. This review provides a summary of recent developments in the synthesis of sulfones.
1 Introduction
2 Classical Methods and Variants
2.1 Oxidation of Sulfides
2.2 Aromatic Sulfonylation
2.3 Alkylation/Arylation of Sulfinates
2.4 Addition to Alkenes and Alkynes
2.5 Miscellaneous Methods
3 Metal-Catalyzed Coupling Reactions
4 Sulfone Synthesis by C–H Functionalization
5 Sulfur Dioxide Based Three-Component Approaches
6 Biological Synthesis of Sulfones
7 Conclusion
Sulfones are versatile intermediates in organic synthesis and important building blocks in the construction of biological active molecules or functional materials. This review provides a summary of recent developments in the synthesis of sulfones.
1 Introduction
2 Classical Methods and Variants
2.1 Oxidation of Sulfides
2.2 Aromatic Sulfonylation
2.3 Alkylation/Arylation of Sulfinates
2.4 Addition to Alkenes and Alkynes
2.5 Miscellaneous Methods
3 Metal-Catalyzed Coupling Reactions
4 Sulfone Synthesis by C–H Functionalization
5 Sulfur Dioxide Based Three-Component Approaches
6 Biological Synthesis of Sulfones
7 Conclusion